Menetrier Disease
Definition
- Massive gastric foveolar hyperplasia involving the full thickness of the mucosa
Diagnostic Criteria
- Foveolar hyperplasia of gastric body
- Foveolae corkscrew shaped and may be cystically dilated
- May extend into submucosa
- Produces giant gastric folds
- Foveolae corkscrew shaped and may be cystically dilated
- Atrophy of oxyntic glands
- Decreased acid secretion
- Mucous cells extend to the base of the glands
- Variable edema
- Mixed inflammatory infiltrate, usually mild
- Hypertrophic muscularis mucosae may extend into lamina propria
- Intestinal metaplasia may occur late in disease
- Granulomas may occur late in disease
- Antrum spared in adults, involved in children
- Pediatric cases associated with Cytomegalovirus
- Present in blood, urine, stomach
Clinical
- Decreased acid production
- Hypoproteinemia, hypoabuminemia, peripheral edema
- GI bleeding
- Adults – chronic, insidious onset
- Children – sudden onset
- Often self-limited
Robert V Rouse MD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342
Original posting : September 9, 2009
