Rhabdomyosarcoma
Clinical
- See Grading for determination of prognostic groups
- Incidence: The most common soft tissue sarcoma of childhood; up to 10% of all childhood malignancies
- Distribution by subtypes in children
- Embryonal 68%, alveolar 31%, others rare
- Different distribution in adults
- Pleomorphic 43%, embryonal 34%, alveolar 23%
- Usually presents as a painless mass
- May be symptomatic depending on organ of involvement (i.e. bladder - urinary dysfunction, orbit - diplopia, etc.)
- 34% present with localized disease (5-year survival rate >80%)
- 30% present with distant metastases (5-year survival rate 33%)
- Effect of anaplasia on 5-year overall survival:
- No anaplasia – 68%
- Focal anaplasia – 60%
- Diffuse anaplasia – 45%
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