Mucinous Cystic Neoplasm of the Pancreas
Grading / Staging / Report
- Grading
- Adenoma grade
- Single layer of mucinous columnar cells
- Flat or irregular undulations
- No well formed papillae
- No cytologic atypia
- Borderline grade
- Papillary projections
- Pseudostratification
- Nuclear crowding
- Moderate cytologic atypia
- Irregular hyperchromatic nuclei
- One or more nucleoli
- May be focal
- Carcinoma in situ grade
- Multilayered epithelium
- Cribriform architecture
- Marked nuclear pleomorphism
- Frequent mitotic figures
- Loss of intracytoplasmic mucin
- May be focal
- Staging is not relevant unless invasive carcinoma is present
- If present, follow TNM staging for carcinoma
- Report
- Grade
- Presence or absence of invasive carcinoma
- Give type and size
- For noninvasive lesions
- Note that there appears to be about a 5% risk of developing carcinoma even if margins negative
- Suggest clinical followup
- Adenoma grade
- Single layer of mucinous columnar cells
- Flat or irregular undulations
- No well formed papillae
- No cytologic atypia
- Borderline grade
- Papillary projections
- Pseudostratification
- Nuclear crowding
- Moderate cytologic atypia
- Irregular hyperchromatic nuclei
- One or more nucleoli
- May be focal
- Carcinoma in situ grade
- Multilayered epithelium
- Cribriform architecture
- Marked nuclear pleomorphism
- Frequent mitotic figures
- Loss of intracytoplasmic mucin
- May be focal
- If present, follow TNM staging for carcinoma
- Grade
- Presence or absence of invasive carcinoma
- Give type and size
- For noninvasive lesions
- Note that there appears to be about a 5% risk of developing carcinoma even if margins negative
- Suggest clinical followup
