Papillary Adenoma
Differential Diagnosis
- Papillary renal cell carcinoma
- Clear cell renal cell carcinoma
- Carcinoma associated with end stage kidney disease
Papillary Renal Cell Carcinoma | Papillary Adenoma |
---|---|
>1.5 cm diameter | Papillary lesion ≤1.5 cm REQUIRED |
May have any nuclear grade | Nuclear grade 1 or 2 REQUIRED |
Conventional Clear Cell Renal Cell Carcinoma | Papillary Adenoma |
---|---|
No size cutoff for clear cell tumors | Papillary lesion ≤1.5 cm, clear cells not permitted |
May be high or low grade | Must be no higher than grade 2 |
CK7, AMACR/racemase/P504S neg to focal | CK7, AMACR/racemase/P504S pos |
Two types of renal cell carcinoma are associated with end stage renal disease
- One is composed of cells with clear cytoplasm, the other of cells with high grade nuclear features
- Neither feature is permitted in renal adenomas