Angiosarcoma of the Breast
Supplemental Studies
Immunohistology
- CD31 is the most specific vascular endothelial marker
- Carcinomas and stromal cells are negative
- Reaction with histiocytes may be confused with sheets of neoplasm
- Most sensitive marker in high grade cases
- CD34 is relatively specific
- Carcinomas are negative
- Frequent, extensive benign stromal cell reactivity may make interpretation difficult
- Less sensitive than CD31 in high grade cases, but exceptions to this rule do occur
- Factor VIII related antigen
- Less sensitive than CD31 and CD34 in neoplasms
