Prior to entering veterinary school, Dr. Nagamine obtained a Ph.D. in Ecology from the University of California, Davis (1979), obtained postdoctoral training in endocrinology, developmental genetics, immunology, and molecular biology of the mouse at the Memorial Sloan-Kettering Cancer Center (NYC), Institut Pasteur (France), and the Howard Hughes Medical Institute at the University of California, San Francisco and was an Assistant Professor of Cell Biology at the Vanderbilt University School of Medicine. His research focuses on using mouse models to study murine and human infectious diseases. These colloborative studies include dengue virus, adeno-associated virus, coxsackie virus, enterohepatic helicobacters, campylobacters, and anaplasma.

The laboratory mouse is the most widely used mammalian model for biomedical research and comprises over 90% of the non-aquatic, laboratory animals at Stanford.  As Director of the Rodent Health Surveillance Program and the Director of Rodent Services, my research and clinical expertise is in mouse reproductive biology, mouse models of mammalian sex determination and sexual differentiation, and mouse models of infectious diseases.  Past research focused on the molecular genetics underpinning a mouse model of XY sex reversal and the effect of the bacterial pathogen Helicobacter hepaticus on chemical and genetic models of colon cancer.  Current collaborative research is the development of a mouse model for dengue virus to study the relationship between autophagy and dengue virus virulence.