Serous Macrocystic / Oligocystic Adenoma of the Pancreas
Definition
- Benign pancreatic neoplasm composed of a small number of large cysts lined by bland clear cells
Alternate/Historical Names
- Ill-demarcated serous adenoma
- Macrocystic serous cystadenoma
- Serous macrocystic adenoma
- Serous oligocystic ill-defined adenoma
Diagnostic Criteria
- Generally poorly circumscribed
- Stroma may entrap other elements
- May be hyalinized
- No invasion of local organs
- Stroma may entrap other elements
- One or a few large cysts
- Most 1-3 cm, up to 8 cm reported
- Lined by single layer of cuboidal cells with clear cytoplasm
- Abundant glycogen (PAS +, diastase digestible)
- Rarely eosinophilic cytoplasm
- May be denuded
- Bland cytology
- Round/oval nuclei
- No mitotic figures
- Lacks prominent central scar
Robert V Rouse MD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342
Original posting/updates: 1/4/07, 4/25/09, 1/4/12
