Juvenile Papillomatosis
Definition
- A discrete multicystic breast lesion typically ocurring in young females
Alternate/Historical Names
- Swiss cheese disease
Diagnostic Criteria
- Discrete mass
- Circumscribed but not encapsulated
- Usually solitary
- Rarely multicentric and bilateral
- 1 to 8 cm diameter
- Large numbers of cysts, up to 2 cm
- "Swiss cheese disease"
- Frequently contain foamy histiocytes
- Cyst lining variably hyperplastic
- Frequently papillary with epithelial bridges
- Hyperplasia may be atypical in 10% of cases
- Both epithelial and myoepithelial layers present
- Apocrine metaplasia may be prominent
- Occasionally contains sclerosing adenosis or radial scar
- Necrosis and mitotic figures may be seen in rare cases
- Typically in adolescent or young adult female
Richard L Kempson MD
Robert V Rouse MD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342
Original posting:: May 27, 2006