Ductal Carcinoma in Situ of the Breast
Variant: Endocrine Ductal Carcinoma In Situ
Alternate Name
- Neuroendocrine ductal carcinoma in situ
Diagnostic Criteria
- Over half of the cells must be chromogranin or synaptophysin positive
- Usually papillary or solid archictecture
- May be spindled
- May have microacini or rosettes
- Regular round nuclei, stippled chromatin
- Frequently has extracellular mucin
- May be associated with papillomas
- Associated invasive carcinoma usually mucinous or neuroendocrine
