Monoclonal Light Chain and Heavy Chain Deposition Diseases
Definition
- Plasma cell neoplasm that secretes immunoglobulin that deposits in tissues and causes tissue damage but does not form an amyloid-type beta-pleated sheet structure
Alternate/Historical Names
- Randall disease
Diagnostic Criteria
- Non-fibrillary, amorphous eosinophilic material
- Congo Red stain negative
- Serum M component present in 85%
- Monoclonal light or heavy chain deposits that cause organ dysfunction
- Heavy chain deposition disease is very rare, so the following must be ruled out
Dita Gratzinger MD PhD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342
Initial posting/updates : 9/1/07, 4/18/10
