aDepartment of Genetics and Genomic SciencesbCardiovascular Research Center, Mount Sinai School of Medicine, New York, New YorkcDepartments of GeneticsdBioengineering, Stanford University, Stanford, CaliforniaeDivision of Endocrinology, Diabetes and Nutrition, University of Maryland School of MedicinefGeriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland, USAgDepartment of Pharmacology, Université Pierre et Marie Curie-Paris 6, INSERM UMR S 956, Pitié-Salpêtrière University Hospital, Paris, France