Neoplasm composed primarily of small B lymphocytes frequently with moderately abundant pale cytoplasm (monocytoid cells) and a predilection for involvement of mucosal sites
Other than monocytoid cells, lymphoepithelial lesions, marginal zone involvement and follicular colonization, most of the findings are rather nonspecific for distinction from other small B lymphomas
Small to medium sized cells
Nuclei round or indented
Clumped chromatin
Cytoplasm inconspicuous to moderately abundant and pale (monocytoid)
Plasmacytoid differentiation frequent
Can be extensive, resembling plasmacytoma
Many head and neck plasmacytomas may actually be marginal zone lymphomas
May form lymphoepithelial lesions
Infiltration of non-neoplastic epithelium by lymphoma cells
Three or more lymphoid cells
Destruction of epithelium
Typically increased eosinophilia
Relatively specific finding if present
May involve marginal zones of reactive follicles
Cells in marginal zone frequently monocytoid
Infiltrate usually extends from marginal zone into adjacent regions
May become interfollicular
May show follicular colonization
Infiltration of germinal centers by lymphoma cells
Typically large cells
In spite of large cells, no worsening of prognosis
Relatively specific finding if present
Lacks specific markers of other small cell lymphomas
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