The Pfeffer Lab is studying how human cells put receptors in the right place.
This basic research is important for our understanding of a number of diseases
including cancer, diabetes, heart disease, neurological disorders and stroke.
We study Rab GTPases that regulate all aspects of receptor trafficking and
signal regulation as well as peptide hormone and neurotransmitter secretion.
We also study the Golgi complex, a processing station for 30% of the proteins
encoded by the human genome, and the roles of NPC1 and NPC1L1 proteins
in cholesterol uptake.